|
Symbol Name ID |
Dctn1
dynactin 1 MGI:107745 |
| Darker colors indicate more annotations |
| Human Phenotypes | Dysphagia |
Pseudobulbar paralysis |
Spasticity |
Degeneration of anterior horn cells |
Abnormal lower motor neuron morphology |
Amyotrophic lateral sclerosis |
Degeneration of the lateral corticospinal tracts |
Abnormality of extrapyramidal motor function |
Bradykinesia |
Parkinsonism |
Fasciculations |
Tremor |
Vocal cord paralysis |
Dysarthria |
Depression |
Anxiety |
Suicidal ideation |
Apathy |
Inappropriate behavior |
Personality changes |
Disinhibition |
Hyperorality |
Dementia |
Frontotemporal dementia |
Sleep abnormality |
Insomnia |
Sleep apnea |
Hyperreflexia |
Primitive reflex |
Akinesia |
Dystonia |
Short stepped shuffling gait |
| Disease(s) Associated with DCTN1 | ||||||||||||||||||||||||||||||||
| amyotrophic lateral sclerosis type 1 | ||||||||||||||||||||||||||||||||
| autosomal dominant distal hereditary motor neuronopathy 14 | ||||||||||||||||||||||||||||||||
| Perry syndrome |
| Mouse Phenotypes | increased susceptibility to neuronal excitotoxicity |
abnormal neural tube morphology |
microgliosis |
astrocytosis |
abnormal motor neuron morphology |
decreased motor neuron number |
motor neuron degeneration |
abnormal neuromuscular synapse morphology |
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| Availability | Mouse Genotype | ||||||||
| Dctn1tm1Cai/Dctn1tm1Cai | |||||||||
| Dctn1tm1Cai/Dctn1+ | |||||||||
| Dctn1tm2.1Cai/Dctn1tm2.1Cai Tg(Thy1-cre)1Vln/? (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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